Decrement of Transcriptome Level in Epithelial Tight Junction Claudin and Occludin as an Epithelial-Mesenchymal Transition Signature for Colorectal Cancer Biomarker

Background: Colorectal cancer is a common and fatal disease worldwide with increasing diagnosed cases yearly. Moreover, about 90% of deaths associated cancers occur due to metastasis, which overcomes tight junction proteins such as claudin occludin. The present study aimed evaluate the significance occludin expression change in human colorectal cancer. Materials Methods: In this case-control study, 38 patients were compared normal samples regarding levels genes by polymerase chain reaction. Results: significantly decreased tumor samples. Conclusion: level could be considered an influential factor turning healthy tissues into cancerous cells.